论文部分内容阅读
对金属硫蛋白的研究表明:胎仔一如母体也可产生金属硫蛋白,而且它与锌的贮存和调节有关。本文作者进一步研究了镉对孕兔及胎仔的毒作用(体重、肝、肾、胎盘等脏器重量及体长)、在亚细胞器的分布、金属硫蛋白的产生及其中镉、锌含量的变化。孕兔处死前48小时皮下一次分别注射氯化镉0、0.125、0.25和0.50 mg/kg,纯度99.999%(由于1.0 mg/kg引起胎仔死亡率高,故取消了该剂量组)。结果表明0.50 mg/kg剂量组胎仔的体重、肝重、肾重以及胎仔体长均明显低于对照组(P<0.01)。但其肝脏/体重和肾脏/体重之比未见明显改变。
Metallothionein studies have shown that fetal embryo can also produce metallothionein as a parent, and it is related to zinc storage and regulation. The authors further studied the toxic effects of cadmium on pregnant rabbits and fetuses (body weight, liver, kidney, placenta and other organ weights and body length), distribution in subcellular organelles, production of metallothionein, and changes in cadmium and zinc contents . Pregnant rabbits were injected with 0, 0.125, 0.25 and 0.50 mg / kg of cadmium chloride subcutaneously 48 hours prior to sacrifice, with a purity of 99.999% (this dose group was abolished due to a high fetal mortality rate of 1.0 mg / kg). The results showed that body weight, liver weight, kidney weight and fetal body length of 0.50 mg / kg dose group were significantly lower than those of the control group (P <0.01). However, no significant change in liver / body weight and kidney / body weight ratio was observed.