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肾素-血管紧张素系统(RAS) RAS(图1)包括肾素、血管紧张素原、血管紧张素I(ATI)、血管紧张素Ⅱ(ATⅡ),以及血管紧张素转化酶(ACE)等五大部分组成。肾素是一种糖蛋白,分子量为42kD,主要在肾脏合成。循环中的肾素是以非活化的前肾素(porenin)形式存在,约占90％以上,经胰蛋白酶处理后形成活化肾素。血管紧张素原是肾素作用的底物,在肝脏合成,是一种分子量52～62kD之间的巨大α_2球蛋白,其N端10个氨基酸经肾素裂解后形成AT I。肺部含有丰富的ACE。后者是一种分
The renin-angiotensin system (RAS) RAS (Figure 1) includes renin, angiotensinogen, angiotensin I (ATI), angiotensin II (AT II), and angiotensin converting enzyme Five major components. Renin is a glycoprotein with a molecular mass of 42 kD, mainly synthesized in the kidneys. Circulating renin is in the form of non-activated pre-renin (porenin), accounting for more than 90%, activated by trypsin to form activated renin. Angiotensinogen is a substrate of renin and is synthesized in the liver. It is a giant α 2-globulin with a molecular mass of 52-62 kD. AT of its N terminal 10 amino acids is formed by renin cleavage. The lungs are rich in ACE. The latter is a kind of points