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目的 为了证实人胚胎胸腺是否存在降黑素受体（ＭＲ）以及是否通过Ｇ蛋白介导的信息转导系统。方法 应用放射配体法测定中期引产人胎儿中枢性免疫器官——胸腺的ＭＲ。结果 它们具有高亲和力，平衡解离常数为（９．１±１．９） ｐｍｏｌ／Ｌ，低结合容量，蛋白的最大结合容量为（０．７４±０．２８） ｆｍ ｏｌ／ｍｇ；动力学研究显示具可逆性及可饱和性；特异性研究表明对降黑素（Ｍ）及其激动剂具高度特异性，符合特异结合位点的全部条件，而Ｇ蛋白抑制剂（ＧＴＰｒＳ）使［１２５Ｉ］Ｍ 特异结合位点量明显降低。结论 人类免疫器官是Ｍ 作用的靶器官，Ｍ 对免疫系统的作用应该是直接的，ＭＲ属于Ｇ蛋白系统。
Purpose To confirm the presence of dementia receptors (MRs) in the human embryonic thymus and whether or not it passes through the G-protein-mediated information transduction system. Methods Radioimmunoassay was used to determine the MR of thymus, a central immune organ in human fetuses during mid - term labor induction. As a result, they have high affinity and the equilibrium dissociation constant is (9.1 ± 1.9) pmol / L with low binding capacity and the maximum protein binding capacity is (0.74 ± 0.28) fmol / mg. Kinetics Studies have shown reversibility and saturability; specific studies have shown that it is highly specific for melatonin (M) and its agonists and conforms to all conditions of specific binding sites whereas GTP inhibitors ([125I ] M specific binding sites decreased significantly. Conclusion The human immune organ is the target organ of M action. The effect of M on the immune system should be direct. MR belongs to the G protein system.