论文部分内容阅读
储脂类冬眠动物在每年夏季大量进食以储存脂肪,在冬季通过冬眠降低代谢并缓慢消耗脂肪。冬眠动物在育肥晚期或冬眠早期表现出高血糖及胰岛素抵抗等症状,但在冬眠结束后胰岛素敏感性明显增强。冬眠可改善胰岛素抵抗症状,这可能是通过改变Akt信号转导通路、葡萄糖转运蛋白(GLUT)和PPARγ/PGC-1α转录复合体的表达来实现的。在肥胖及相关代谢疾病迅速增长的今天,深入研究冬眠动物改善胰岛素抵抗症状的调控机制,可为治疗肥胖病人的胰岛素抵抗提供新的途径。
Lipid-bearing hibernation animals eat heavily in summer to store fat, hibernate in the winter to lower metabolism and slow fat consumption. Hibernating animals showed symptoms such as hyperglycemia and insulin resistance in late fattening or early hibernation, but their insulin sensitivity increased significantly after hibernation. Hibernation improved insulin resistance, possibly by altering the expression of Akt signaling pathway, glucose transporter (GLUT) and PPARγ / PGC-1α transcriptional complex. With the rapid growth of obesity and related metabolic diseases today, further studies on the regulation mechanism of hibernating animals to improve the symptoms of insulin resistance may provide a new approach for the treatment of insulin resistance in obese patients.