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目的研究硫酸镁联合小剂量阿司匹林治疗早发型子痫前期的效果以及对母婴的影响。方法 52例早发型子痫前期患者,随机分为观察组和对照组,各26例。观察组患者接受硫酸镁联合小剂量阿司匹林治疗;对照组患者接受硫酸镁治疗,比较两组患者的治疗效果。结果观察组患者肝、肾功能损害、子痫、早产分别为2、1、0、2例,均少于对照组的9、7、4、10例,差异具有统计学意义(P<0.05)。观察组新生儿窒息3例、新生儿低体重3例,均少于对照组的9、14例,差异具有统计学意义(P<0.05)。结论硫酸镁联合小剂量阿司匹林治疗重度子痫前期有助于改善患者临床症状,降低早产、子痫等不良妊娠结局的发生率,具有良好的应用价值。
Objective To study the effect of magnesium sulfate in combination with low-dose aspirin on early-onset preeclampsia and its effect on mothers and infants. Methods 52 cases of early-onset preeclampsia were randomly divided into observation group and control group, with 26 cases in each group. Patients in the observation group received magnesium sulfate in combination with low-dose aspirin, and patients in the control group received magnesium sulfate. The therapeutic effect was compared between the two groups. Results The liver and renal dysfunction, preeclampsia and preterm birth in the observation group were 2, 1, 0 and 2 cases, respectively, which were less than those in the control group (9, 7, 4 and 10 cases, respectively) . In the observation group, 3 cases of neonatal asphyxia and 3 cases of neonatal hypoplasia were fewer than 9 and 14 cases of the control group, respectively. The difference was statistically significant (P <0.05). Conclusion Magnesium sulfate combined with low-dose aspirin in the treatment of severe preeclampsia can improve the clinical symptoms and reduce the incidence of adverse pregnancy outcomes such as premature birth and eclampsia, which has a good value.