【摘 要】
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Mycobacterium tuberculosis (MTB) infection remains a serious infectious disease worldwide,causing 8.8 million new infections and 1.45 million deaths in 2010 [1]
【机 构】
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Laboratory Center, The Third People’s Hospital of Changzhou, Changzhou 213001, China
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Mycobacterium tuberculosis (MTB) infection remains a serious infectious disease worldwide,causing 8.8 million new infections and 1.45 million deaths in 2010 [1].The emergence of drug-resistant strains of MTB poses a significant threat to the control of the disease globally.Multidrugresistant MTB (MDR-TB),defined as being resistant to at least rifampicin (RMP) and isoniazid (INH),and extensively drug-resistant TB (XDR-TB),defined as being additionally resistant to any fluoroquinolone and one injectable secondline drug,are associated with higher treatment failure rates.China is the second largest nation in terms of the number of the MTB infection,and 9.3％ of the cases are MDR-TB [2].MDR-TB arises from spontaneous chromosomal mutations at low frequency,but clinical MDR-TB largely occurs as a result of man-made selection during disease treatment of these genetic alterations through erratic drug supply,suboptimal physician prescription,and poor patient adherence [3].
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