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目的 衡量端粒酶活性和肺癌的相关性 ,综合评价端粒酶活性作为肺癌诊断标记物的效度。方法 检索并筛选出 2 8篇有关端粒酶活性和肺癌的流行病学资料 ,用meta分析 (包括Fleiss固定效应模型或D L随机效应模型 )合并效应尺度OR ,并汇总端粒酶活性在肺癌诊断中的特异度和灵敏度 ,评价该肿瘤标记物的效度。结果 D L法计算OR合并为 66.43( 38.48～ 10 4.5 3) ;Fleiss法将同质的 2 5项研究结果加权合并后 ,肺癌组累积 1361例 ,对照组累积 132 1例 ,检测灵敏度为 0 .7987,特异度为 0 .934 1。结论 端粒酶是一种较理想的诊断性肿瘤标志物 ,该研究结果为将端粒酶活性检测纳入肺癌筛检计划提供一定的理论依据。
Objective To measure the correlation between telomerase activity and lung cancer, and to evaluate the validity of telomerase activity as a diagnostic marker for lung cancer. METHODS: Twenty-eight epidemiological data on telomerase activity and lung cancer were searched and screened. Meta-analyses (including Fleiss’s fixed-effect model or DL random effect model) were used to combine effector scale OR and to summarize telomerase activity in the diagnosis of lung cancer. The specificity and sensitivity in the evaluation of the validity of the tumor marker. RESULTS: The DL method calculated the OR to be 66.43 (38.48 to 104.5 3). The Fleiss method weighed and combined the results of 25 homogenous studies. The lung cancer group accumulated 1361 cases, the control group accumulated 132 cases, and the detection sensitivity was 0.797. With a specificity of 0.934 1. Conclusion Telomerase is an ideal diagnostic tumor marker. The study results provide a theoretical basis for the detection of telomerase activity in lung cancer screening program.