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目的：比较脂必妥与多烯康治疗高脂血症的疗效。方法：高脂血症１０８例分为２组。脂必妥组５４例（男性３７例，女性１７例；年龄４８±ｓ７ａ），给脂必妥片１．０５ｇ，ｐｏ，ｔｉｄ，共４ｗｋ。多烯康组（男性３６例，女性１８例；年龄４８±８ａ），给多烯康１．３５ｇ，ｐｏ，ｔｉｄ×４ｗｋ。结果：脂必妥组用药２ｗｋ开始ＴＣ，ＴＧ，ＬＤＬ－ｃｈ，均有显著下降（Ｐ＜０．０１），ＨＤＬ－ｃｈ显著升高（Ｐ＜０．０５）；用药４ｗｋ均进一步下降或升高。多烯康组用药２ｗｋ和４ｗｋ后ＴＣ，ＴＧ，ＬＤＬ－ｃｈ亦有显著下降（Ｐ＜０．０１），ＨＤＬ－ｃｈ无显著变化。结论：脂必妥调脂作用优于多烯康。
OBJECTIVE: To compare the efficacy of lipidbide and polyene in the treatment of hyperlipidemia. Methods: Hyperlipemia 108 cases were divided into two groups. Lipid in the group of 54 patients (37 males and 17 females; age 48 ± s7a), to Lipid Tablets 1.05g, po, tid, a total of 4wk. Duoenkang group (36 males and 18 females; age 48 ± 8a) were given polyenecan 1.35g, po, tid × 4wk. Results: The levels of TC, TG and LDL-ch in the lipopeptics group decreased significantly (P <0.01) and HDL-ch increased significantly at 2 weeks (P <0.05) high. The levels of TC, TG and LDL-ch also dropped significantly after 2wk and 4wk treatment (P <0.01), while there was no significant change in HDL-ch. Conclusion: The effect of lipid-lipid regulation is better than that of doxycycline.