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目的评价地诺前列酮与双球囊导管用于促宫颈成熟的临床疗效和安全性。方法将208名Bishop评分≤6的产妇随机分为试验组105例和对照组103例。试验组用双球囊导管促宫颈成熟,对照组将1枚地诺前列酮10 mg置于阴道穹窿的深处用于促宫颈成熟。记录在24 h内分娩的相关数据,比较2组的临床疗效和不良反应发生率。结果试验组24 h内经阴道分娩成功的比例较对照组高(68.57%vs 49.51%,P<0.05)。剖宫产率在2组间差异无统计学意义(23.81%vs 26.21%,P>0.05)。试验组催产素和硬膜外镇痛的使用率较对照组高(P<0.05),而对照组子宫张力过大和宫缩过频发生率较试验组高(P<0.05)。结论双球囊导管用于促宫颈成熟较地诺前列酮可以增加24 h内阴道分娩成功率。
Objective To evaluate the clinical efficacy and safety of dinoprostone and dual balloon catheters in promoting cervical ripening. Methods 208 women with Bishop score ≤6 were randomly divided into experimental group (105 cases) and control group (n = 103). The experimental group with double balloon catheter to promote cervical ripening, the control group will be a dinoprostone 10 mg placed in the depth of the vaginal vault for cervical ripening. Record the data about childbirth within 24 h, compare the clinical efficacy and the incidence of adverse reactions in the two groups. Results The proportion of successful vaginal delivery within 24 hours in experimental group was higher than that in control group (68.57% vs 49.51%, P <0.05). There was no significant difference in cesarean section rate between the two groups (23.81% vs 26.21%, P> 0.05). The use of oxytocin and epidural analgesia in the experimental group was higher than that in the control group (P <0.05), while the incidence of uterine hypertrophy and uterine contractions in the control group was higher than that in the experimental group (P <0.05). Conclusions Double balloon catheters can increase the success rate of vaginal delivery within 24 h when cervix is ripened compared with norgeprostone.