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目的:探讨食管贲门双源癌组织中Rb蛋白表达的变化特征及其意义。方法:采用免疫组化ABC法和组织病理学方法,分析河南食管癌高发区林州市30例食管贲门双源癌患者Rb蛋白的表达状况。结果:在30例双源癌患者中,食管鳞癌和贲门腺癌组织中Rb阳性率分别为46.7%(14/30)和40%(12/30),差异无统计学意义(χ2=0.272,P>0.05)。食管和贲门癌组织Rb一致阳性率为36.7%(26/30),一致阴性率为50%(15/30),食管鳞癌和贲门腺癌组织中Rb的表达相关(P<0.05)。结论:该地区食管癌和贲门癌存在较高的Rb一致性变化,提示二者可能具有相似的发病因素和分子机制。
Objective: To investigate the changes of Rb protein expression in esophageal and gastric cardia carcinoma and its significance. Methods: Immunohistochemical ABC method and histopathological method were used to analyze the expression of Rb protein in 30 cases of esophageal and gastric cardia double cancer in Linzhou, a high incidence area of esophageal cancer in Henan province. Results: The positive rate of Rb in esophageal squamous cell carcinoma and gastric cardia adenocarcinoma was 46.7% (14/30) and 40% (12/30) respectively in 30 cases of double-stranded carcinoma, the difference was not statistically significant (χ2 = 0.272 , P> 0.05). The positive rate of Rb in esophageal and gastric cardia was 36.7% (26/30), and the negative rate was 50% (15/30). The expression of Rb in esophageal squamous cell carcinoma and gastric cardia adenocarcinoma was correlated with the expression of Rb (P <0.05). Conclusion: There is a high Rb consistency in esophageal and gastric cardia cancers in this area, suggesting that both may have similar pathogenesis and molecular mechanisms.