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由siRNAs介导的RNAi是低等生物体内的一种基因调控方式。siRNAs诱导RNAi发生的效率有赖于其结构、序列及末端碱基修饰情况。本文作者简略论述了能在体内诱导高效RNAi现象的siRNAs结构组成的特征及其可能影响siRNAs作用效率的因素。
RNAi mediated by siRNAs is a way of gene regulation in lower organisms. The efficiency of siRNAs in inducing RNAi depends on its structure, sequence and terminal base modification. The authors briefly discuss the features of siRNAs that induce efficient RNAi in vivo and the factors that may influence the efficiency of siRNAs.