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目的研究国产A型肉毒毒素(CBTX-A)局部注射治疗小儿痉挛性脑瘫的疗效,副作用。方法选择1000例痉挛性小儿脑性瘫痪患儿,以每组肌肉2.5U/kg用量进行痉挛肌肉局部注射。应用PRS(physicianratingscale)法比较治疗前及治疗后1个月时运动姿势的改善情况。观察治疗中及治疗后的副作用。结果绝大多数患儿治疗后其PRS疗效指标均有不同程度的改善,其有效率为99.7%,P<0.01。除5例(0.5%)注射后短期内患肢无力外,其他均无明显副作用发生。结论CBTX-A局部注射是一种安全、有效、方便灵活、较少副作用的治疗小儿痉挛性脑瘫的好方法。
Objective To study the curative effect and side effects of domestic injection of botulinum toxin type A (CBTX-A) in children with spastic cerebral palsy. Methods One hundred and thirteen children with spastic pediatric cerebral palsy were selected, and local muscle spasm was injected by 2.5 U / kg of muscle in each group. The PRS (physicianratingscale) method was used to compare the improvement of exercise posture before treatment and one month after treatment. Observe the side effects during and after treatment. Results The majority of children with PRS after treatment efficacy indicators have varying degrees of improvement, the effective rate was 99.7%, P <0.01. In addition to 5 cases (0.5%) after injection of limb weakness in the short term, the other no significant side effects. Conclusion CBTX-A local injection is a safe, effective, convenient and flexible, less side effects of treatment of children with spastic cerebral palsy a good way.