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目的:用不同方法(TP-ELISA、TPPA)检测西宁地区老年人梅毒的结果比较分析,通过比较不同梅毒检测方法的敏感性和特异性,选择更合理的方法应用于老年人梅毒患者的检测。方法:搜集于我院临床疑似有梅毒的老年患者300例为病例组;800例有疑似梅毒的中青年组为对照组,分别进行TP-ELISA、TPPA试验。结果:300例老年组用TP-ELISA法检出梅毒阳性59例,阳性率为19.7%,TPPA检出梅毒阳性22例,阳性率为7.33%;800例对照组用TP-ELISA法检出阳性为49例,阳性率为6.13%,TPPA检出阳性为39例,阳性率为4.88%。结论:老年组TP-ELISA法检测的阳性率明显高于中青年组,而用TPPA法检测两组结果无差异,说明梅毒抗体阳性率与年龄、疾病及检测方法有很大的关系,也是造成老年人梅毒抗体易产生假阳性的重要原因。
OBJECTIVE: To compare and analyze the results of syphilis detection in elderly people in Xining with different methods (TP-ELISA, TPPA). To compare the sensitivity and specificity of different syphilis detection methods and select more reasonable methods to detect syphilis in the elderly. Methods: 300 elderly patients with suspected syphilis in our hospital were enrolled as case group. 800 young and middle-aged patients with suspected syphilis were selected as control group and were respectively subjected to TP-ELISA and TPPA. Results: In 300 elderly patients, the positive rate of syphilis was 59.7% with TP-ELISA and 22 with TPPA, the positive rate was 7.33%. The positive rate of TP-ELISA in 800 control subjects was positive 49 cases, the positive rate was 6.13%, TPPA positive was 39 cases, the positive rate was 4.88%. Conclusion: The positive rate of TP-ELISA in the elderly group was significantly higher than that in the middle-aged and young group, while there was no difference between the two groups using the TPPA method, indicating that the positive rate of syphilis antibody has a great relationship with age, disease and detection methods. Syphilis antibodies in the elderly are prone to false positives.