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The influences of Mo contents on mechanical properties,biocorrosion and cytocompatibility of as-cast Mg-6Zn-8.16Y-2.02Mn-xMo (x =0.0,0.1,0.3,0.5,0.7 wt％) alloys were firstly investigated.Appropriate amount of Mo was conducive to grain refinement and the formation of long-period stacking ordered structure with continuous distribution,which was advantageous to mechanical properties and corrosion resistance.Mg-6Zn-8.16Y-2.02Mn-0.3Mo exhibited the ultimate tensile strength of 265.0 MPa,elongation of 13.5％ and the lowest weight loss rate in Hank\'s solution.Moreover,the cell toxicity cultured in 25％ extract was evaluated and the alloy with 0.3 wt％ Mo exhibited the best cytocompatibility.Thus,the alloy was expected to become a novel biodegradable implant material.