论文部分内容阅读
目的:探讨肝病患者肝脏组织白细胞介素18结合蛋白(interleukin-18 binding protein,IL-18BP)的表达水平及临床意义。方法:应用免疫组织化学技术检测41例原发性肝癌、9例慢性乙型肝炎、11例肝硬化、和5例正常肝组织中IL-18BP的表达情况,同时检测患者外周血IL-18BP的含量。结果:原发性肝癌的癌周组织IL-18BP表达量最高,与癌组织、肝硬化组织、慢性肝炎组织和正常肝组织评分值组间比较差异有统计学意义(P<0.01);表达强度:癌周组织>肝硬化>肝癌>慢性肝炎,正常组织无阳性表达(P<0.01)。IL-18BP在组织中的表达和血清中的含量相一致。结论:肝病患者IL-18BP表达水平随病情加重呈递增趋势。
Objective: To investigate the expression of interleukin-18 binding protein (IL-18BP) in liver tissue of patients with liver disease and its clinical significance. Methods: The expression of IL-18BP in 41 cases of primary hepatocellular carcinoma, 9 cases of chronic hepatitis B, 11 cases of cirrhosis and 5 cases of normal liver tissue were detected by immunohistochemistry. Meanwhile, the levels of IL-18BP content. Results: The expression of IL-18BP in pericancerous tissues of primary hepatocellular carcinoma was the highest, with statistical significance (P <0.01). The expression of IL-18BP was significantly higher than that in carcinoma, cirrhosis, chronic hepatitis and normal liver tissue Pericancerous tissue> Liver cirrhosis> Liver cancer> Chronic hepatitis, no positive expression in normal tissues (P <0.01). The expression of IL-18BP in tissues is consistent with that in serum. Conclusion: The level of IL-18BP in patients with liver disease increases with the progression of the disease.