论文部分内容阅读
近二十年来,已系统地从微生物次级代谢产物中,筛选非抗生素类的生物活性物质。这一新的科研领域的开展,一方面为筛选临床有用的新药开辟新的途径,同时也为从分子水平研究生物生理功能提供有效的手段和工具。本文主要就非抗生素类的生物活性物质筛选研究的基本概念、理论根据、筛选流程、一般原则和方法以及研究进展的概况,加以综述和讨论。生物活性物质的基本概念生物活性物质(Bioactive Microbial Pro-
For nearly two decades, non-antibiotic bioactives have been systematically screened from microbial secondary metabolites. This new field of research, on the one hand, opens up new avenues for the screening of clinically useful new drugs and at the same time provides effective tools and tools for the study of bio-physiological functions at the molecular level. In this paper, the basic concepts, theoretical basis, screening process, general principles and methods of non-antibiotic bioactive substances screening and the overview of research progress are summarized and discussed. Basic Concepts of Bioactives Bioactive Microbial Pro-