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为了解腹壁淋巴管对物质转运的功能及其与机体免疫功能状态之间的关系,进行了此实验.取成年Wistar大鼠10只,随机分为两组,A组动物以4mg环磷酰胺/100g体重的剂量隔日腹腔注射一次.B组注射生理盐水.动物于第三次注射后,开始以1ml/100g体重的剂量腹腔注射40%印度墨水.每日一次.连续注射两天.动物经环磷酰胺处理后.腹壁引流淋巴管对腹腔内的碳粒清除速度下降.碳粒滞留于腹腔内,但其一旦进入淋巴管内则即限制于内.而不能由管内向管外扩散.对照组动物腹腔内碳粒清除快,腹壁内很少滞留.但其在淋巴管的引流途中,可以大量向管周扩散.实验证明,抑制机体的免疫功能,可以降低淋巴管的通透性.
To understand the function of lymphatic vessels on the abdominal wall for substance transport and its relationship with immune function, 10 adult Wistar rats were randomly divided into two groups, Group A animals were treated with 4 mg cyclophosphamide / 100g body weight was injected intraperitoneally every other day.The rats in group B were injected with saline.The animals were injected intraperitoneally with 40% Indian ink at a dose of 1ml / 100g after the third injection, once a day for two consecutive days. After the treatment of phosphoramide, the drainage of lymphatics on the abdominal wall decreased the intraperitoneal carbon clearance, while the carbon remained in the peritoneal cavity, but once it entered the lymphatic vessels, it was confined to the inside and could not diffuse out of the tube. Intraperitoneal carbon clearance is fast, little retention in the abdominal wall, but its lymphatic drainage in the way, you can a large number of proliferation to the tube weeks.Experiments have shown that inhibition of the body’s immune function, can reduce lymphatic permeability.