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目的探讨白细胞介素 Ⅱ (IL 2 )和LAK细胞对鼻咽癌 (NPC)放疗后患者细胞免疫功能的影响。方法2 7例放疗后获CR的患者分成2组 :A组 (治疗组 ) ,17例接受IL 2和LAK细胞治疗 ;B组 (对照组 ) ,10例仅予一般治疗。检测两组治疗前后NK活性和CD+ 4/CD+ 8值的变化。结果A组治疗后NK活性和CD+ 4/CD+ 8比值均明显提高 (P <0 .0 5 ) ,B组则无明显变化。结论IL 2和LAK细胞治疗可增加NPC放疗后患者的NK活性 ,对T细胞亚群有调节作用。
Objective To investigate the effects of interleukin-2 (IL-2) and LAK cells on cellular immunity in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Method 27 cases of CR after radiotherapy were divided into two groups: A group (treatment group), 17 patients received IL 2 and LAK cell treatment; B group (control group), 10 cases were treated only. The changes of NK activity and CD + 4 / CD + 8 before and after treatment were detected. Results A group after treatment NK activity and CD + 4 / CD + 8 ratio were significantly increased (P <0. 05), B group had no significant change. Conclusions IL-2 and LAK cell therapy can increase the NK activity of patients after NPC radiotherapy and have a regulatory effect on T cell subsets.