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目的 研究突变型P5 3蛋白在软组织肉瘤中的表达及意义。方法 应用P5 3蛋白单克隆抗体对 78例软组织肉瘤进行免疫组化观察分析。结果 其总阳性率为 43 5 8% ,其中在脂肪肉瘤 (47 0 5 % )、横纹肌肉瘤 (46 6 6 % )、纤维肉瘤(45 45 % )中阳性率较高 ,而平滑肌肉瘤中 (7 14% )阳性率较低。同时发现P5 3蛋白的阳性表达与肉瘤的分化程度有关 ,分化愈低其阳性率愈高 ,且在不同类型肉瘤中有一定差别。结论 这提示P5 3抑癌基因突变在软组织肉瘤的发生发展过程中起着重要作用。
Objective To study the expression and significance of mutant P5 3 protein in soft tissue sarcoma. Methods 78 cases of soft tissue sarcoma were immunohistochemically observed with P53 protein monoclonal antibody. Results The positive rate was 43 5 8%, of which the positive rate was higher in liposarcoma (47 0 5%), rhabdomyosarcoma (46 6 6%) and fibrosarcoma (45 45%), while in leiomyosarcoma 14%) lower positive rate. Also found that the positive expression of P53 protein and the degree of differentiation of sarcoma, the lower the higher the positive rate of differentiation, and in different types of sarcoma there is a certain difference. Conclusion This suggests that the mutation of P53 oncogene plays an important role in the development of soft tissue sarcoma.