【摘 要】
：
The autonomic nervous system controls various internal organs and executes crucial functions through sophisticated neural connectivity and circuits.Its dysfunction causes an imbalance of homeostasis and numerous human disorders.In the past decades,great e
【机 构】
：
Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200
论文部分内容阅读
The autonomic nervous system controls various internal organs and executes crucial functions through sophisticated neural connectivity and circuits.Its dysfunction causes an imbalance of homeostasis and numerous human disorders.In the past decades,great efforts have been made to study the structure and functions of this system,but so far,our understanding of the classification of autonomic neuronal subpopulations remains limited and a precise map of their connectivity has not been achieved.One of the major challenges that hinder rapid progress in these areas is the complexity and heterogeneity of autonomic neurons.To facilitate the identification of neuronal subgroups in the autonomic nervous system,here we review the well-established and cutting-edge technologies that are frequently used in peripheral neuronal tracing and profiling,and discuss their operating mechanisms,advantages,and targeted applications.
其他文献
The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A (BoNT/A) on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single facial injection of BoNT/A induced a rap
Depression is a debilitating psychiatric disorder with a huge socioeconomic burden,and its treatment relies on antidepressants including selective serotonin reuptake inhibitors (SSRIs).Recently,the melatonergic system that is closely associated with the s
Nervous systems endow animals with cognition and behavior.To understand how nervous systems control behavior,neural circuits mediating distinct functions need to be identified and characterized.With superior genetic manipulability,Drosophila is a model or
Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder (MDD).The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features,modeled as Gaussian Markov
The hypothalamic paraventricular nucleus (PVN) is a crucial region involved in maintaining homeostasis through the regulation of cardiovascular,neuroendocrine,and other functions.The PVN provides a dominant source of excitatory drive to the sympathetic ou
Early-onset epilepsy is a neurological abnormality in childhood,and it is especially common in the first 2 years after birth.Seizures in early life mostly result from structural or metabolic disorders in the brain,and the genetic causes of idiopathic seiz
Dear Editor,rnHuman prion diseases consist of sporadic,genetic/familial,and acquired forms.The familial form accounts for 5％-15％ of all human prion diseases,including familial Creutzfeldt-Jacob disease (fCJD),Gerstmann-Str(a)ussler-Scheinker syndrome,and
Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network.We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the auto
Accumulating evidence suggests that obesity is associated with chronic pain.However,whether obesity is associated with acute inflammatory pain is unknown.Using a well-established obese mouse model induced by a highfat diet,we found that:(1) the acute ther
In addition to restoration of bladder,bowel,and motor functions,alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI).Currently,however,the treatment of chronic pain