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Dear Editor,rnHuman prion diseases consist of sporadic,genetic/familial,and acquired forms.The familial form accounts for 5％-15％ of all human prion diseases,including familial Creutzfeldt-Jacob disease (fCJD),Gerstmann-Str(a)ussler-Scheinker syndrome,and fatal familial insomnia (FFI) [1-3].All genetic prion diseases are directly associated with mutations (point-mutation or insertion) in the PRNP gene located on human chromosome 20 and encodes prion protein (PrP).So far,＞55 mutations in the PRNP gene have been described [4].Some PRNP mutations and their related genetic prion diseases have been reported worldwide,while others show clear region-or ethnicity-associated features.