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收集１９ 例急性期慢性阻塞性肺疾病（ Ｃ Ｏ Ｐ Ｄ）患者，６ 例 Ｃ Ｏ Ｐ Ｄ缓解期患者以及１０ 例正常对照者的痰液，以酶联免疫吸附法 （ Ｅ Ｌ Ｉ Ｓ Ａ） 测定其痰液白细胞介素 １６ （ Ｉ Ｌ１６） 水平， 以探讨 Ｉ Ｌ１６ 在 Ｃ Ｏ Ｐ Ｄ发病机制中的作用及其对 Ｃ Ｏ Ｐ Ｄ气道炎症的临床意义。结果， Ｃ Ｏ Ｐ Ｄ 患者急性发作期痰 Ｉ Ｌ１６ 水平（１ ２３３±４９２４４ ｎｇ／ Ｌ） 和缓解期 （１ ２３２±５１３５３ ｎｇ／ Ｌ） 均明显高于正常对照者 （６６０７７±３１２１１ ｎｇ／ Ｌ） （ Ｐ＜ ００５ ）。此外， Ｃ Ｏ Ｐ Ｄ患者痰液 Ｉ Ｌ１６ 水平与 Ｆ Ｅ Ｖｌ呈负相关（ｒ＝ － ０．４３， Ｐ＜ ００５ ）。以上结果表明， Ｉ Ｌ１６ 参与了 Ｃ Ｏ Ｐ Ｄ气道炎症的发病过程， 其机制可能与激活 Ｔ 淋巴细跑有关。
The sputum of 19 patients with chronic obstructive pulmonary disease (C O P D), 6 patients with C O P D remission and 10 normal control subjects were collected and their serum levels were determined by enzyme-linked immunosorbent assay (ELISA) To determine the sputum IL-16 levels in order to investigate the role of IL-16 in the pathogenesis of COPD and its clinical significance of COPD airway inflammation. Results The levels of sputum IL-16 (1 233 ± 49244 ng / L) and remission (1 232 ± 51353 ng / L) in patients with COPD were significantly higher than those in healthy controls (660 77 ± 31211 ng / L) (P <005). In addition, sputum IL-16 levels in COPD patients were negatively correlated with F E Vl (r = - 0.43, P <005). The above results show that IL-16 involved in the pathogenesis of COPD airway inflammation, the mechanism may be related to the activation of T lymphocyte breakdown.