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Background: Despite improvements in the emergency treatment of myocardial infarction(MI), early mortality and morbidity remain high. The antiplatelet agent clopidogrel adds to the benefit of aspirin in acute coronary syndromes without ST-segment elevation, but its effects in patients with ST-elevation MI were unclear. Methods: 45 852 patients admitted to 1250 hospitals within 24 h of suspected acute MI onset were randomly allocated clopidogrel 75 mg daily(n=22 961)or mat ching placebo(n=22 891)in addition to aspirin 162 mg daily. 93%had ST-segment elevation or bundle branch block, and 7%had ST-segment depression. Treatment w as to continue until discharge or up to 4 weeks in hospital(mean 15 days in surv ivors)and 93%of patients completed it. The two prespecified co-primary outcome s were:(1)the composite of death, reinfarction, or stroke; and(2)death from any cause during the scheduled treatment period. Comparisons were by intention to tr eat, and used the log-rank method. This trial is registered with ClinicalTrials .gov, number NCT00222573. Findings: Allocation to clopidogrel produced a highly significant 9%(95%CI 3-14)proportional reduction in death, reinfarction, or stroke(2121[9.2%] clopidogrel vs 2310[10.1%] placebo; p=0.002), corresponding to nine(SE 3)fewer events per 1000 patients treated for about 2 weeks. There was also a significant 7%(1-13)proportional reduction in any death(1726[7.5%] vs 1845[8.1%]; p=0.03). These effects on death, reinfarction, and stroke seemed consistent across a wide range of patients and independent of other treatments being used. Considering all fatal, transfused, or cerebral bleeds together, no significant excess risk was noted with clopidogrel, either overall(134[0.58%] vs 125[0.55%]; p=0.59), or in patients aged older than 70 years or in those given fibrinolytic therapy. Interpretation: In a wide range of patients with acute MI, adding clopidogrel 75 mg daily to aspirin and other standard treatments(such as fibrinolytic therapy)safely reduces mortality and major vascular events in hospital, and should be considered routinely.
Background: Despite improvements in the emergency treatment of myocardial infarction (MI), early mortality and morbidity remain high. The antiplatelet agent clopidogrel adds to the benefit of aspirin in acute coronary syndromes without ST-segment elevation, but its effects in patients with ST- Elevations MI were unclear. Methods: 45 852 patients admitted to 1250 hospitals within 24 h of critical acute MI an intermittently allocated clopidogrel 75 mg daily (n = 22 961) or mat ching placebo (n = 22 891) in addition to aspirin 162 93% had ST-segment elevation or bundle branch block, and 7% had ST-segment depression. Treatment w as to continue until discharge or up to 4 weeks in hospital (mean 15 days in survivors) and 93% of The two prespecified co-primary outcomes were: (1) the composite of death, reinfarction, or stroke; and (2) death from any cause during the scheduled treatment period. Comparisons were by intention to tr eat, and used the log-rank method. This trial Allocation to clopidogrel produced a highly significant 9% (95% CI 3-14) proportional reduction in death, reinfarction, or stroke (2121 [9.2%] clopidogrel vs 2310 [10.1% There was also a significant 7% (1-13) proportional reduction in any death (1726 [7.5%] vs placebo; p = 0.002), corresponding to nine (SE 3) fewer events per 1000 patients treated for about 2 weeks. 1845 [8.1%]; p = 0.03). These effects on death, reinfarction, and stroke found consistently across a wide range of patients and independent of other treatments being used. Considering all fatal, transfused, or cerebral bleeds together, no significant excess either in patients aged older than 70 years or in those given fibrinolytic therapy. Interpretation: In a wide range of patients with risk of being clopidogrel, either either (134 [0.58%] vs 125 [0.55%]; p = 0.59) acute MI, adding clopidogrel 75 mg daily to aspirin and other standard treatments (such as fibrinolytic therapy) securely reduces and major vascular events in hospital, and should be considered routinely.