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目的 :观察布替萘芬乳膏剂治疗豚鼠皮肤真菌病的疗效。方法 :本实验共建立皮肤真菌病豚鼠感染模型 45处 ,分别是 1%布替萘芬乳膏治疗组 ,1%萘替芬乳膏治疗组 ,1%联苯苄唑乳膏治疗组 ,1%克霉唑软膏治疗组和空白对照组 ,疗程为 14d,药物治疗结束后观察复发状况。结果 :布替萘芬乳膏 10 d临床治愈率比联苯苄唑乳膏和萘替芬乳膏高 2 2 .3% ,但无显著性差异 (P>0 .0 5 ) ,与克霉唑软膏差异有显著性意义 (P<0 .0 5 )。治愈后继续观察复发症状 3周 ,布替萘芬复发数远小于其它各组药物。结论 :布替萘芬作为抗皮肤浅表真菌药物有很好的发展前景。
Objective: To observe the efficacy of butenafine cream in the treatment of skin fungal disease in guinea pigs. Methods: Forty-five models of dermatophytosis guinea pig infection were established in this experiment, which were 1% butenafine cream treatment group, 1% naftifine cream treatment group, 1% bifonazole cream treatment group, 1 % Clotrimazole ointment treatment group and blank control group, the course of treatment was 14d, and the relapse status was observed after drug treatment. Results: The clinical cure rate of butenafine cream 10d was 22.3% higher than that of bifenazole cream and naftifine cream, but no significant difference (P> 0.05) There was significant difference between the two groups (P <0.05). Continue to observe the recurrence of symptoms cured after 3 weeks, the number of budesonide recurrence is much smaller than the other groups of drugs. Conclusion: Butenafine as anti-skin superficial fungi drugs have good prospects for development.