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目的调查分析海南地区高血压患者家族相关基因单核苷酸多态性(SNP)。方法采用SNP基因芯片技术,检测高血压患者及其直系亲属血管紧张素原(AGT)、血管紧张素转移酶(ACE)、内皮型一氧化氮合成酶(eNOS)、内皮素2(ET-2)、心钠素(ANP)、心钠素受体(NPRC)6个相关基因18种多态性分布情况。结果其中AGT(M235T)、ACE(I/D)多态性基因型分布与对照组比较具有显著统计学差异(P<0.05),而6个高血压相关基因等位基因频率分布与对照组比较差异均无显著统计学意义。结论海南人群中所检测的6个相关基因的基因住点的基因频率与其他地区和国家相比具有自己的特点,AGT(M235T)基因TT型和ACE(I/D)基因DD型可能与原发性高血压有关,是海南岛居民原发性高血压家系人群发病的危险因素之一。
Objective To investigate and analyze the single nucleotide polymorphisms (SNPs) of family related genes in hypertensive patients in Hainan Province. Methods The SNP gene chip was used to detect the expression of angiotensinogen (AGT), angiotensin-converting enzyme (ACE), endothelial nitric oxide synthase (eNOS) and endothelin-2 ), ANP and NPRC 18 polymorphism distribution. Results The genotype distributions of AGT (M235T) and ACE (I / D) polymorphisms were significantly different from those of the control group (P <0.05), while alleles of 6 hypertension-related genes were compared with those of the control group There was no significant difference between the two groups. Conclusion The frequency of gene loci of 6 related genes detected in Hainan population has its own characteristics compared with other regions and countries. TT gene of AGT (M235T) gene and DD genotype of ACE (I / D) Hypertension is one of the risk factors for the incidence of essential hypertension in Hainan Island residents.