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本研究用单抗HIM82对中性粒细胞（PMN）呼吸爆发的早期调控，发现HIM82（30μg／ml）对佛波酯（PMA）激活的PMN产生的O2-、H2O2分别可下调至（44．00±8．9）％（n=8，P＜0．01）和（65．16±15.41）％（n=8，P＜0．01），对因呼吸爆发产生的活性氧物质（reactiveoxygenspecies，ROS）引起质膜中性内肽酶（NEP）的纯化作用（inactivation）[活性下降（43．29±9．41）％，n＝8，P＜0．01]有防护作用[活性恢复至（6648±15.53）％，n=8，P＜0．05]。结果表明该单抗对PMA激发PMN呼吸爆发产生O2-、H2O2有明显的降调节作用，也表明质膜上相应分化抗原分子对PMN功能特别是对激活呼吸爆发的机构有重要影响。
In this study, the early regulation of neutrophil (PMN) respiration burst with monoclonal antibody HIM82 found that HIM82 (30μg / ml) was down-regulated to O2- and H2O2 by PMMA activated by phorbol myristate (PMA), respectively. (N = 8, P <0.01) and (65.16 ± 15.41)% (n = 8, P <0.01). The levels of reactive oxygen species , ROS) caused a protective effect of plasma membrane neutral endopeptidase (NEP) [inactivation (43.29 ± 9.41)%, n = 8, P <0.01] To (6648 ± 15.53)%, n = 8, P <0.05]. The results showed that the monoclonal antibody induced PMA-induced respiratory burst PMN produce O2-, H2O2 significantly down regulation, also shows that the corresponding plasma membrane antigen molecules on the PMN function, especially for the activation of respiratory burst organizations have a significant impact.