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目的:建立小儿鼻炎颗粒的质量标准。方法:采用薄层色谱法对制剂中的白芷、藁本、防风进行定性鉴别;采用高效液相色谱法对制剂中的欧前胡素进行含量测定。结果:白芷、藁本、防风3味药材的薄层色谱鉴别专属性强,分离度好;欧前胡素在0.01293～0.1164μg范围内线性关系良好,r=0.9999,平均回收率为98.48%,RSD为1.55%。结论:本方法简单易行,重复性好,专属性强,可用于小儿鼻炎颗粒的质量控制。
Objective: To establish the quality standard for pediatric rhinitis particles. Methods: The qualitative identification of Radix paeoniae Alba, T. sibiricus, and wind-breaking in the preparation was carried out by TLC. The content of imperatorin in the preparation was determined by high performance liquid chromatography. RESULTS: The specificity of TLC, Takimotomoto, and 3 flavors of T. velutipes herbs was strong, and the degree of separation was good. The linear relationship of imperatorin in the range of 0.01293-0.1164 μg was good, r=0.9999, and the average recovery was 98.48%. The RSD is 1.55%. Conclusion: This method is simple, easy to repeat, good in specificity, and can be used for quality control of pediatric rhinitis particles.