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目的 探讨经皮睾丸精子抽吸术在临床上的应用。方法 135例患者分为3组:梗阻性无精子症组(OA组)71例,先天性无精子症组(CC组)23例,原发性无精子症组(IA组)41例,所有患者均做经皮睾丸精子抽吸术及单精子注射术。结果 通过经皮睾丸精子抽吸术(PTAS)获得精子的平均密度为73.542.59/μl,平均活动率为(1.51.17)%(范围1%~5%),共1263个成熟卵子行ICSI,获得849个正常胚胎(正常受精率为67.2%)。在OA组中,71例患者行79周期,32例怀孕。在CC组中,23例患者行28周期,9例怀孕。在IA组中,41例患者行41周期,8例怀孕。结论 PTSA合ICSI是一种治疗梗阻性无精子症的有效手段,且梗阻性无精子症患者的妊娠率高于特发性无精子症患者。
Objective To investigate the clinical application of percutaneous testicular sperm aspiration. Methods A total of 135 patients were divided into 3 groups: 71 patients with obstructive azoospermia (OA), 23 patients with congenital azoospermia (CC), 41 patients with primary azoospermia (IA) Patients were treated with percutaneous testicular sperm aspiration and sperm injection. Results The average density of spermatozoa obtained by percutaneous testicular sperm aspiration (PTAS) was 73.542.59 / μl and the average activity rate was 1.51.17% (range 1% -5%). A total of 1263 mature eggs were performed ICSI , 849 normal embryos were obtained (normal fertilization rate was 67.2%). In the OA group, 71 patients underwent 79 cycles and 32 were pregnant. In the CC group, 23 patients underwent 28 cycles and 9 were pregnant. In group IA, 41 patients underwent 41 cycles and 8 were pregnant. Conclusions PTSA combined with ICSI is an effective method for the treatment of obstructive azoospermia, and the pregnancy rate of obstructive azoospermia is higher than that of idiopathic azoospermia.