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选择性环氧合酶-2（COX－2）抑制剂已成为寻找副作用小的、非甾体类抗炎药的研究方向。美洛昔康与氯诺者康是两种结构不同的昔康类非奋体抗炎药，所具有的消炎镇痛作用及良好的胃肠道耐受性与它们对COX－2的选择性抑制作用有关。作者报道了美洛昔康和氧诺昔康对COX－2的选择性抑制作用及相应的药效学和药动学性质。
Selective cyclooxygenase-2 (COX-2) inhibitors have become the search for less-toxic, non-steroidal anti-inflammatory drugs. Meloxicam and lornoxicam are two different kinds of oxcarbazone non-steroidal anti-inflammatory drugs with anti-inflammatory and analgesic effects and good gastrointestinal tolerance and their selectivity for COX-2 Inhibition related. The authors report the selective inhibition of meloxicam and oxynocix on COX-2 and the corresponding pharmacodynamic and pharmacokinetic properties.