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本文报告在60例对标准抗心律失常药物治疗无效的间歇性室性心动过速患者中,10例(17％)有二尖瓣脱垂综合征。这10例患者似为二尖瓣脱垂的恶性变异型。由此提示,二尖瓣脱垂综合征伴发的心律失常必须分别单独考虑,二尖瓣脱垂的存在并不一定表示心律失常呈良性。方法:60例对传统抗心律失常药物治疗无效的患者,在病史、体检和常规化验后,作超声心动图和24小时随身心电图记录。患者并作冠状动脉造影、左室造影和希氏束电图。在作希氏束电图时给予新的抗心律失常药物——茚满丙二胺(Aprindine),其后改为口服,根据血清浓度、疗效和副作用调节剂量。患者每1～4周随访一次,作24小时心电图记录。结果:60例患者中10例有二尖瓣脱垂综合征,
This paper reports 10 patients (17%) with mitral valve prolapse syndrome in 60 patients with intermittent ventricular tachycardia who are refractory to standard antiarrhythmic drug therapy. These 10 patients appeared to be malignant variants of mitral valve prolapse. This suggests that mitral valve prolapse syndrome associated with arrhythmias must be considered separately, the presence of mitral valve prolapse does not necessarily mean arrhythmia was benign. METHODS: Sixty patients who did not respond to conventional antiarrhythmic drug therapy were recorded by echocardiography and 24-hour portable electrocardiography after medical history, physical examination, and routine tests. Patients and for coronary angiography, left ventricular angiography and His bundle electrogram. A new antiarrhythmic drug, Aprindine, was given as a His bundle test, then changed to oral and the dose was adjusted for serum concentration, efficacy and side effects. Patients were followed up every 1 to 4 weeks for 24-hour ECG recording. Results: 10 of 60 patients had mitral valve prolapse syndrome,