分光光度法测量人体异烟肼血药浓度

来源 :天津医科大学学报 | 被引量 : 0次 | 上传用户:rmbsaxn
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
本文报道用分光光度法测量人体异烟肼血药浓度。用三氯醋酸沉淀血浆中蛋白,上清液中异烟肼与1,2-萘醌-4-磺酸钠反应呈色,于470nm测其吸收度。采用标准曲线法计算血药浓度。其平均相对回收率为101.6%,RSD为3.4%。方法简便、快速、较准确。以此法测量一般片与缓释片的异烟肼在体内血药浓度的变化,结果较好。 This article reports the spectrophotometric measurement of human isoniazid plasma concentration. Plasma protein was precipitated with trichloroacetic acid, the isoniazid in the supernatant was reacted with sodium 1,2-naphthoquinone-4-sulfonate, and the absorbance was measured at 470 nm. Using standard curve method to calculate plasma concentration. The average relative recovery was 101.6% with a RSD of 3.4%. Method is simple, fast, more accurate. This method to measure the general tablets and sustained release tablets of isoniazid in plasma concentration changes, the result is better.
其他文献
本文采用反相高效液相色谱法考察了氧氟沙星滴耳剂的稳定性。该法简便、迅速、专属性强、精密度好,制剂回收率为99.97%。经光照、高温、低温和加速试验,结果表明:本制剂对冷和热稳定,对
《人才开发》杂志创刊二十二年,由上海市人事局主管,上海人才研究会主办,国内外公开发行。《人才开发》杂志是集政治性、思想性、理论性、知识性于一体的人才学类综合性期刊
Baicalin is a type of flavonoid,which is extracted from dried roots of Scufellarla baicalensis Georgi.Baicalin has been shown to exhibit anti-microbial and anit
Objective:Midge egg masses are reported to support non-pathogenic strains of the cholera pathogen.Vibrio cholera(V.cholera).Mosquito born diseases have been rep
Objective:To evaluate the anti-inflammatory property of leaves of Sansevieria liberica Ger. and Labr.and to ascertain the toxicity and phytochemical profiles of
在祥云躲藏深处 有一方雪域净土 格桑花尽情吐露 龙头琴弹响祝福 哦唐古拉山雅鲁藏布 老阿妈叩首虔诚朝圣的路 跳起欢腾的锅庄舞 点燃髯火一齐欢呼 歌唱幸福生活新蓝图 是谁
采用高效液相色谱法,以益康唑为内标,在YWG-C18柱上使其得到分离,测定栓剂中酮康唑的含量,方法回收率为101.87±1.66%。本法可用于栓剂的质量控制。 High performance liquid chromatography with
以ADP,胶原,AA和TMVA诱导血小板聚集,利用电子显微镜观察普罗托品对兔血小板超微结构的影响。结果表明:普罗托品明显抑制ADP,胶原,AA和TMVA诱导的兔血小板聚集、形态的改变和颗粒内含物的释放,说明:普罗
[Objective] This study was to investigate the effects of fermentation time on the contents of two main toxic ingredients of fatty oil and total protein in Lingb
中国唱片广州公司近日宣布:第一个签约中国唱片公司的瑞典歌后索菲娅·格林将于11月12日在中山纪念堂召开中国巡回演唱的首场演唱会。届时,索菲娅将与小朋友以及神秘嘉宾同