幽门螺杆菌对功能性消化不良患者体表胃电的影响

• 作 者: 王承党 陈玉丽 吴婷 刘豫瑞 陆岽 庄则豪
• 机 构: 福建医科大学附属第一医院消化科
• 出 处: 华人消化杂志
• 发表日期: 1998年07期
• 关键词: 幽门螺杆菌 功能性消化不良 患者 体表胃电

目的探讨功能性消化不良（ＦＤ）患者的体表胃电变化规律及幽门螺杆菌（Ｈｐ）感染对其的影响．方法应用ＷＣＤ４Ｂ胃电分析仪观察５３例Ｈｐ阳性ＦＤ，３８例Ｈｐ阴性ＦＤ和２６名Ｈｐ阴性健康志愿者在空腹和进餐后的体表胃电频率、振幅改变及其时空变化．结果ＦＤ患者（不论Ｈｐ阳性或阴性）空腹及餐后胃电节律紊乱率明显高于对照组，而餐后的紊乱率增高更明显（Ｈｐ阳性ＦＤ组：空腹１０６％，餐后３０１％；Ｈｐ阴性ＦＤ组：空腹１２５％，餐后２９４％；对照组：空腹４５％，餐后６６％，Ｐ＜００１）．尽管ＦＤ组的平均振幅、最高振幅比与对照组无显著差异（Ｐ＞００５），但ＦＤ组中餐后振幅无明显增高的比例明显高于对照组（Ｈｐ阳性ＦＤ组：胃窦１３４％，胃体１６９％；Ｈｐ阴性ＦＤ组：胃窦１５８％，胃体１１５％；对照组：胃窦３８％，胃体３８％，Ｐ＜００５），而且ＦＤ组的餐后振幅恢复时间明显延长（Ｈｐ阳性ＦＤ组：胃窦１４７３ｍｉｎ±４３８ｍｉｎ，胃体１５３５ｍｉｎ±４７４ｍｉｎ；Ｈｐ阴性ＦＤ组：胃窦１３９４ｍｉｎ±３４７ｍｉｎ，胃体１４８０ｍｉｎ±４９２ｍｉｎ；对照组：胃窦８７６ｍｉｎ±２５３ｍｉｎ，胃体?

Objective To investigate the changes of body surface and gastric electrical signals in patients with functional dyspepsia (FD) and the influence of Helicobacter pylori (Hp) infection on them. Methods The WCD4B electrogastrograph was used to observe the changes of gastric electrical frequency, amplitude and temporal and spatial changes in 53 Hp-positive FD, 38 Hp-negative FD and 26 Hp-negative healthy volunteers. Results The fasting and postprandial gastric electrical rhythm disorder rate in FD patients (positive or negative of Hp) was significantly higher than that in control group, while the postprandial dysfunction rate increased more significantly (FD group of Hp: fasting 10.6%, postprandial 30 1%; Hp negative FD group: fasting 12  5%, postprandial 29  4%; control group: fasting 4  5%, postprandial 6  6%, P <0  01). Although the average amplitude and maximum amplitude ratio in FD group were not significantly different from those in control group (P> 0.05), the proportion of post-prandial amplitude in FD group was significantly higher than that in control group (Hp positive FD group: gastric antrum 13 4%, 16.9% of gastric body; Hp negative FD group: 15.8% of gastric antrum and 11.5% of gastric body; control group: 38% of gastric antrum, 38% of gastric body, P <0 05), and the recovery time of postprandial amplitude in FD group was significantly prolonged (Hp positive FD group: gastric antrum 1473min ± 438min, gastric body 1535min ± 474min; Hp negative FD group: gastric antrum 1394min ± 347min, 1480min ± 492min in gastric body, while in control group: 876min ± 253min in gastric antrum,