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空气、水、食品和一些消费品中的致癌物亚硝胺对公众健康的危害正在增长,这种危害的增长与亚硝胺前身物广泛分布于环境中相平行。硝酸盐和二级胺在体内、体外都可合成亚硝胺,硝酸盐起亚硝化剂的作用,据研究还表明在体外血浆、肺匀浆中的二级胺也能被氧化氮(NO_x)亚硝化。作者观察了ICR小鼠,管饲2 mg吗啉(MOR)后,立即置于NO_2染毒柜中,然后全鼠用液氮冰冻处理制成粉末,匀浆提取后测N-亚硝基吗啉(NMOR)。作者的初步研究结果证实,外源性胺MOR通过吸入的NO_2可在小鼠体内亚硝化而
The public health risks of carcinogenic nitrosamines, which are carcinogens in air, water, foodstuffs and some consumer products, are on the rise, and their damage is paralleled by the widespread distribution of nitrosamine precursors in the environment. Nitrates and secondary amines can be synthesized in vitro and in vivo nitrosamines, nitrates play the role of nitrosation agent, according to the study also showed that in vitro plasma, lung homogenate secondary amines can also be nitrogen oxide (NO_x) Nitrification. The authors observed the ICR mice, 2 mg morpholine (MOR) after tube feeding, immediately placed in NO 2 exposure cabinet, and then the whole mouse was treated with liquid nitrogen and frozen to form a powder, homogenate after extraction test N-nitroso (NMOR). The authors preliminary findings confirm that exogenous amine MOR can be nitrosated in mice by inhaled NO 2