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目的探讨Ｐ－糖蛋白在胃癌中的表达意义。方法应用Ｓ－Ｐ免疫组化方法研究８１例原发性胃癌Ｐ－糖蛋白的表达变化的关系，结果发现Ｐ－糖蛋白阳性染色率为２８．４％，Ｐ－糖蛋白的阳性染色与胃癌的分化程度、浸润深度、淋巴结转移及胃癌细胞增殖活性无关，而与胃癌的ＣＥＡ表型显著相关（Ｐｅａｒｓｏｎ列联系数＝０．３５，Ｐ＜０．０５）。癌旁正常胃粘膜胃腺底部Ｐ－糖蛋白阳性染色率为７．４％。结论化疗前的胃癌患者自发性地存在Ｐ－糖蛋白过表达，可能是部分患者在治疗初始阶段即对化疗缺乏敏感性的一种标志。
Objective To investigate the significance of P-glycoprotein expression in gastric cancer. Methods The expression of P-glycoprotein in 81 cases of primary gastric cancer was studied by S-P immunohistochemistry. The positive staining rate of P-glycoprotein was 28.4%. Positive staining of P-glycoprotein and gastric cancer were found. The degree of differentiation, depth of invasion, lymph node metastasis, and proliferation activity of gastric cancer cells were not related, but significantly correlated with the CEA phenotype of gastric cancer (Pearson column contact number = 0.35, P < 0.05). The positive staining rate of P-glycoprotein at the bottom of gastric adenocarcinoma normal gastric mucosa was 7.4%. Conclusion The spontaneous expression of P-glycoprotein in gastric cancer patients before chemotherapy may be a sign of the lack of sensitivity to chemotherapy in some patients at the initial stage of treatment.