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为了研究丹参酮ⅡA(TanⅡA)对大鼠出血性休克再灌注肾损伤 (HS RRI)的保护作用 ,采用修改的YU法制备大鼠HS RRI模型 ,SD大鼠 30只随机分为TanⅡA高剂量组 (LT)、中剂量组 (MT)、低剂量组 (ST)、溶剂对照组 (P)、复苏 2 4h组 (SR2 4)共 5组 ,观察复苏后 3h的血清尿素氮 (BUN)、肌酐 (SCr)、尿量 (Urinevolume ,UV)的变化 ,以及 2 4h的肾组织病理形态学改变。结果表明 ,各组在休克末的失血量和再灌注后 30min的平均动脉压(MAP)均无差异性 ,TanⅡA能降低再灌注后 3h的BUN、SCr ,减轻 2 4h时的肾组织病理损伤 ,以低剂量的作用最佳 ,中、高剂量则次之 ;对尿量作用不明显。TanⅡA对HS RRI有肯定的保护作用
In order to study the protective effect of tanshinone IIA (Tan IIA) on hemorrhagic shock-reperfusion kidney injury (HS RRI) in rats, a rat model of HS RRI was prepared using a modified YU method. Thirty SD rats were randomly divided into high-dose Tan IIA groups. LT, medium-dose group (MT), low-dose group (ST), solvent control group (P), resuscitation 24h group (SR24) 5 groups, serum urea nitrogen (BUN), creatinine (3 hours after resuscitation) were observed. Changes in SCr), urine volume (Urinevolume, UV), and pathological changes in kidney tissue at 24 hours. The results showed that there was no difference in blood loss at the end of shock and mean arterial pressure (MAP) at 30 min after reperfusion. TanIIA could reduce BUN, SCr at 3 h after reperfusion, and reduce renal pathological injury at 24 h after reperfusion. The effect was best at low dose, followed by medium and high doses; the effect on urine volume was not obvious. TanIIA has a positive protective effect on HS RRI