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大脑内环境的稳定是维护神经细胞和神经胶质细胞正常结构和功能的基础,也是实现大脑正常功能的必要条件。脑组织的炎症(inflammation)是影响大脑内环境稳定的重要因素。大量研究显示:脑组织中,多不饱和脂肪酸(polysaturated fatty acid,PUFA)可通过抗炎、抗氧化等作用,保护大脑的正常功能。尤其近来发现:特殊促愈合介质(specialized pro-resolving mediators,SPMs)是一类具有特殊抗炎作用的生物活性分子,可能是n-3 PUFA抗炎的重要分子基础,并通过脑组织中的神经胶质细胞,发挥抗炎作用。这已成为PUFA抗炎功能研究的一个重要方向。
The stability of the brain environment is the basis for the maintenance of the normal structure and function of nerve cells and glial cells, but also the necessary conditions for the normal function of the brain. Inflammation of the brain tissue is an important factor that affects the stability of the environment in the brain. Numerous studies have shown that: Polyunsaturated fatty acids (PUFA) in brain tissue can protect the normal brain function through anti-inflammatory and anti-oxidant effects. In particular, it has been recently found that specialized pro-resolving mediators (SPMs) are a class of bioactive molecules with specific anti-inflammatory effects and may be important molecular basis for the anti-inflammatory effect of n-3 PUFA. Glial cells, play an anti-inflammatory effect. This has become an important direction of PUFA anti-inflammatory function.