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目的探讨多精受精对体外受精-胚胎移植(IVF-ET)临床结局的影响。方法回顾性分析在我院行IVF-ET治疗的资料,根据多精受精率分为四组:0组;>0,≤10%组;>10%,≤20%组;>20%组,比较各组的受精率、第三天的可用胚胎率、种植率以及妊娠率。结果四组的胚胎种植率及临床妊娠率均无显著性差异(29.91%vs35.85%,29.91%vs33.83%,29.91%vs32.43%,P>0.05;47.50%vs48.71%,47.50%vs53.13%,47.50%vs45.40%P>0.05).。但当多精受精率>10%,正常受精率显著下降(72.37%vs68.49%,72.37%vs55.42%;P<0.001);多精受精率>20%,可用胚胎率显著低于≤10%组(52.25%v48.63%,P=0.0472)。结论多精受精对胚胎移植率和临床妊娠率没有显著影响,但过高的多精受精率会降低可用胚胎率。
Objective To investigate the effect of sperm injection on clinical outcome of IVF-ET. Methods The data of IVF-ET treatment in our hospital were retrospectively analyzed. According to the fertilization rate, they were divided into four groups: 0 group,> 0, ≤10%,> 10%, ≤20%,> 20% The fertilization rate, available embryo rate, implantation rate and pregnancy rate on the third day were compared between groups. Results There was no significant difference in embryo implantation rate and clinical pregnancy rate among the four groups (29.91% vs35.85%, 29.91% vs33.83%, 29.91% vs32.43%, P> 0.05; 47.50% vs48.71%, 47.50 % vs53.13%, 47.50% vs45.40% P> 0.05). However, when the fertilization rate was more than 10%, the normal fertilization rate significantly decreased (72.37% vs68.49%, 72.37% vs55.42%; P <0.001), the fertilization rate was more than 20%, the available embryo rate was significantly lower than 10% group (52.25% v48.63%, P = 0.0472). Conclusions Sperm injection did not significantly affect embryo transfer rate and clinical pregnancy rate, but excessive fertilization rates reduced the available embryo rate.