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Matrix metalloproteinase-9(MMP-9)and p53 genes play an essential role in the multi-step process of tumorigenesis in lung cancer.Single nucleotide polymorphisms(SNPs)of MMP-9 and p53 genes are associated with the risk and progression of many cancers.In this study,we evaluated the association of the R279Q polymorphism of MMP-9 or the A1/A2 polymorphism of p53 gene with the risk of no-small-cell lung cancer(NSCLC)in Hart population of Northeast China.We examined the frequency of SNPs in the two kinds of genes of 50 patients with NSCLC and 50 cancer-free controls frequency-matched by age and sex.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique was used to determine the genotypes.The results indicate that the 279RR genotype in MMP-9 gene and the A1/A2 genotype in p53 gene show a significantly increased risk of NSCLC.Therefore,the MMP-9 279RR and p53 A1/A2 genotypes may be used as markers for susceptibility to NSCLC in Han population of Northeast China.