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目的探讨产前诊断染色体核型危险因素,为评估产前诊断指征综合风险提供准确依据。方法对931例进行产前诊断的临床资料进行分析,得出各指征相对应的异常检出率;并通过logistic回归分析获得高危产前诊断指征。结果染色体核型异常检出率为4.83%。Logistic分析后发现父母染色体结构异常、NT增厚、B超示发育异常、唐氏征临界风险是染色体异常的高危因素。结论产前诊断风险评估能够科学有效地辅助临床遗传咨询工作,从而达到提高人口素质与生命质量的目的。
Objective To investigate the risk factors of prenatal diagnosis of karyotype and to provide an accurate basis for assessing the comprehensive risk of prenatal diagnosis. Methods The clinical data of 931 prenatal diagnosis were analyzed and the anomaly detection rate of each indication was obtained. Logistic regression analysis was used to obtain the indications of high-risk prenatal diagnosis. Results The detection rate of chromosomal abnormalities was 4.83%. Logistic analysis found that the parent chromosome structure abnormalities, NT thickening, B ultrasound showed abnormalities, Down’s syndrome critical risk is the risk of chromosomal abnormalities. Conclusions The risk assessment of prenatal diagnosis can assist the clinical genetic counseling work scientifically and effectively so as to achieve the purpose of improving population quality and quality of life.