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生长抑素受体(SSTR)在多种消化系统肿瘤组织高度表达。生长抑素及其类似物能通过配体与受体的相互作用与SSTR特异性结合,采用放射性核素标记的生长抑素类似物可与靶向肿瘤表面高密度的SSTR结合的特性所开发的生长抑素受体显像(SRS)、生长抑素受体介导放射性核素靶向治疗等技术,对表达SSTR的消化道肿瘤及其转移瘤的诊断及鉴别诊断较其他常规方法敏感性高,特异性强。并能对此类肿瘤进行治疗及监测疗效,故应用前景广阔。
Somatostatin receptor (SSTR) is highly expressed in a variety of digestive system tumors. Somatostatin and its analogs can specifically bind to SSTRs through ligand-receptor interactions. The use of radionuclide-labeled somatostatin analogs to develop binding properties to high-density SSTRs targeting tumor surfaces Somatostatin receptor imaging (SRS), somatostatin receptor-mediated radionuclide targeted therapies and other technologies, the expression of SSTR in the diagnosis and differential diagnosis of digestive tract tumors and metastases than other conventional methods, high sensitivity Strong specificity. And can treat and monitor the efficacy of such tumors, so the application prospect is broad.