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目的:观察止哮汤联合舒利迭治疗支气管哮喘的临床疗效。方法:选用符合支气管哮喘中西医诊断标准的患者60例,随机分为2组各30例,治疗组采用中药止哮汤口服联合舒利迭吸入治疗,对照组采用舒利迭吸入加用甲泼尼龙片口服治疗。疗程均为14天。观察2组临床疗效、咳喘症状改善情况,以及呼气峰流速(PEF)日间变异率、支气管扩张试验结果,及血清肿瘤坏死因子-α(TNF-α)水平变化。结果:治疗组显效19例,有效10例,无效1例,总有效率为96.67%。对照组显效8例,有效13例,无效9例,总有效率70.00%。2组总有效率比较,差异有非常显著性意义(P<0.01),治疗组疗效优于对照组。治疗后对2组中显效、有效患者白天喘息症状消失时间、夜间喘息症状缓解时间进行比较,结果显示,治疗组白天喘息症状消失时间、夜间喘息症状缓解时间较对照组短,2组比较,差异有非常显著性意义(P<0.01),提示止哮汤对支气管哮喘患者的喘息表现有较好的改善作用。治疗前2组患者血清TNF-α含量比较,差异无显著性意义(P>0.05),治疗后2组血清TNF-α含量比较,差异有非常显著性意义(P<0.01),提示止哮汤能够降低支气管哮喘患者血清TNF-α含量。结论:止哮汤可清肺化痰,止咳平喘及调节炎症因子,联合舒利迭治疗哮喘作用明显。
Objective: To observe the clinical efficacy of Zhixu decoction combined with seretide in the treatment of bronchial asthma. Methods: Sixty patients with bronchial asthma diagnostic criteria were randomly divided into two groups of 30 patients. The treatment group was treated with traditional Chinese medicine Zhixiao Decoction combined with seretide inhalation. The control group was treated with sulpiride inhalation plus methylprednisolone Nylon tablets oral treatment. Treatment are 14 days. The clinical curative effect, improvement of cough and asthma symptoms, diurnal variation of expiratory flow rate (PEF), bronchodilator test results, and changes of serum tumor necrosis factor-α (TNF-α) levels were observed. Results: In the treatment group, 19 cases were markedly effective, 10 cases were effective and 1 case was ineffective. The total effective rate was 96.67%. In the control group, 8 cases were markedly effective, 13 cases were effective, 9 cases were ineffective, and the total effective rate was 70.00%. The total efficiency of the two groups, the difference was significant (P <0.01), the treatment group than the control group. After treatment, two groups of effective, effective patients with wheezing disappeared in the daytime time, wheeze relief time at night were compared, the results showed that the treatment group wheezing disappeared during the day time, wheeze relief at night time shorter than the control group, the difference between the two groups (P <0.01), which indicated that Zhixiu Decoction had a better effect on asthmatic patients with wheezing. There was no significant difference in serum TNF-α levels between the two groups before treatment (P> 0.05). There was a significant difference in serum TNF-α levels between the two groups after treatment (P <0.01) Can reduce serum levels of TNF-α in patients with bronchial asthma. Conclusion: Zhixiao Decoction can clear lung phlegm, relieve cough and asthma and regulate inflammatory factors, combined with seretide treatment of asthma significantly.