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肺栓塞(PE)可引起以肺动脉高压、右心衰竭和低氧血症为特征的严重心肺功能障碍.虽然主要有害影响归咎于肺动脉的机械性阻塞,但体液介质的释放并加重肺动脉高压的作用也不容忽视.5-羟色胺(5-HT)可能是肺血管收缩反应的主要体液介质之一.Ketanserin 是一种5-HT 拮抗剂,可特异性抑制血管、支气管和血小板的5-HT_2受体,还有轻度的抗α_1肾上腺素的作用.作者观察了10例急性肺栓塞病人输入Ketan-serin 对心肺的效应。年龄40～69岁,平均57岁。应用Ketanserin 前先静滴肝素500ug/kg/d,不用其他血管活性药物.所有病例均经右心导管进行血流动力学监测.用动脉血和混合性静脉血测定pH、PaO_2、P(?)O_2、PaCO_2、SaO_2和S(?)O_2.结果发现10例病人经肺血管造影证实肺血管阻塞平均45±17%.输
Pulmonary embolism (PE) can cause severe cardiopulmonary dysfunction characterized by pulmonary hypertension, right heart failure, and hypoxemia. Although the major detrimental effects are due to the mechanical obstruction of the pulmonary arteries, the release of humoral mediators and aggravating the effects of pulmonary hypertension Can not be ignored.5-HT (5-HT) may be one of the major humoral mediators of pulmonary vasoconstriction.Ketanserin is a 5-HT antagonist that specifically inhibits 5-HT 2 receptors in blood vessels, bronchi and platelets , As well as mild anti-alpha 1-adrenaline effects. The authors observed the effects of Ketan-serin on cardiorespiratory in 10 patients with acute pulmonary embolism. Age 40 ~ 69 years old, average 57 years old. Heparin 500 ug / kg / d was administered intravenously before Ketanserin, without any other vasoactive drugs.All patients were monitored by right heart catheterization for hemodynamics.Part 2, P (?) Were determined by arterial blood and mixed venous blood, O_2, PaCO_2, SaO_2 and S (?) O_2. The results of pulmonary vascular occlusion confirmed by pulmonary angiography in 10 patients were found to be 45 ± 17%