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目的 对正常胰岛及胰岛细胞瘤的某些抗原进行检测 ,并对其临床病理意义进行探讨。方法 采用免疫组化方法对正常胰岛细胞及 5 2例胰岛肿瘤的α 人绒毛膜促性腺激素 (α HCG)、孕激素受体 (PR) ,7B2 ,HISL 19,抗原进行定位观察。结果 发现α HCG在正常胰岛细胞不表达 ,在良性胰岛细胞瘤表达为 3/ 2 8(10 7% ) ;恶性胰岛细胞瘤为 14/ 2 4(5 8 3% )。PR分别为 2 0 / 2 8(71 4% )及 7/ 2 4(2 9% ) ;7B2分别为 2 3/ 2 8(82 1% )及 13/ 2 4(5 4 7% ) ;HISL 19分别为 2 3/ 2 8(82 1% )及 11/ 2 4(4 6 % )。结论 胰岛细胞瘤的某些抗原的表达可能对判断其良恶性有一定的参考价值
Objective To detect some islets of normal islets and islet cell tumors, and to explore its clinicopathological significance. Methods Immunohistochemistry was used to detect the expression of α HCG, PR, 7B2 and HISL 19 in normal islet cells and 52 pancreatic islets. As a result, it was found that α HCG was not expressed in normal islet cells, with 3/28 (10 7%) in benign pancreatic islet cell tumors and 14/2 4 (58 3%) in malignant islet cell tumors. PR were 2 0/2 8 (71 4%) and 7/2 4 (2 9%) respectively; 7B2 were 2 3/2 8 (82 1%) and 13 2 4 (5 4 7% 19 were 2 3/2 8 (82 1%) and 11/2 4 (4 6%) respectively. Conclusions The expression of some antigens in islet cell tumor may be valuable for judging its benign and malignant tumors