Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrys

• 作 者: Sha Xiong Wei Liu Yile Zhou Yo
• 机 构: InstituteofClinicalPharmacology,InstituteofChineseMedicalSciences
• 出 处: 亚洲药物制剂科学(英文)
• 发表日期: 2020年4期
• 关键词: NANOCRYSTALS RESVERATROL Oral absorption Brain permeability Anti-Parkinsonian ef
• 基金项目: Supported by the Guangdong Provincial Natural Science Foundation of China(2018A030310623),Research Fund of University of Macau(MYRG2018-00207-ICMS and SRG2017-00095-ICMS),National Natural Science Foun

Resveratrol(RES),a non-flavonoid polyphenol extracted from a wide variety of plants,exhibits neuroprotective activities against Parkinson’s disease(PD).However,undesirable water solubility of RES reduces its oral bioavailability and demonstrates loweffica