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近十几年胃肠道癌的治疗及预后无明显进展,尚无先进的普查技术使其在早期得到外科治疗,切除肿瘤后应用的多种辅助性化疗未取得满意疗效.术后切除部位复发和腹膜播散是外科治疗的最常见不足.为此提出了术后早期腹腔内化疗做为治疗胃肠道恶性肿瘤防止复发的辅助疗法,其理论基础为:1)切除部位和腹膜表面是最易复发部位,术后即刻应用腹腔内化疗使这些部位与药物充分接触;2)药理学研究提出了最佳化疗比例以消除腹膜表面的残余肿瘤微栓;3)术后期间用药技术简单,可使药物均匀分布于腹膜表面;4)对大多数药物,腹腔内分布不影响全身疗效,且可增加局部作用而不影响全身疾病的控制;5)治疗费用便宜,术后住院期间即可接受化疗,不需再随诊接受其他辅助性化疗;6)不增加或很少增
There has been no significant progress in the treatment and prognosis of gastrointestinal cancer in recent decades. There is no advanced census technique to obtain surgical treatment in the early stage. Various adjuvant chemotherapy applications after tumor removal have not achieved satisfactory results. Postoperative resection site recurrence And peritoneal dissemination is the most common deficiency of surgical treatment. To this end, early postoperative intraperitoneal chemotherapy is proposed as an adjuvant therapy for the prevention of recurrence of gastrointestinal malignancy. Its theoretical basis is: 1) the site of resection and the peritoneal surface are the most Recurrence of the site, immediately after the application of intraperitoneal chemotherapy to make full contact with these sites and drugs; 2) Pharmacological study put forward the best ratio of chemotherapy to eliminate the residual peritoneal tumor microthrombus; 3) during the postoperative period is simple, can be Make the drug evenly distributed on the peritoneal surface; 4) For most drugs, intraperitoneal distribution does not affect the systemic efficacy, and can increase the local effect without affecting the control of the systemic disease; 5) The treatment cost is cheap, and chemotherapy can be accepted after the hospitalization , do not need to follow-up for other adjuvant chemotherapy; 6) do not increase or rarely increase