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目的:探讨非营养性吸吮减少早产儿胃肠外营养相关性胆汁淤积(PNAC)的可行性。方法:选择低体重早产儿60例,随机分为非营养性吸吮加静脉营养及鼻饲喂养组(观察组)和静脉营养及鼻饲喂养组(对照组)各30例,于出生后第1天、第14天分别检测总胆汁酸、肝功能等。结果:在出生后第14天,观察组总胆汁酸、总胆红素、直接胆红素、谷丙转氨酶水平均显著低于对照组(P<0.05);发生胃肠外营养相关胆汁淤积的例数非常显著低于对照组(P<0.01);拔管时间和恢复完全肠内营养时间均较对照组显著缩短(P<0.05)。结论:非营养性吸吮可降低早产儿静脉营养所致总胆汁酸、黄疸、谷丙转氨酶的升高程度,降低PNAC的发生率,缩短拔管和恢复完全肠内营养的时间。
Objective: To explore the feasibility of non-nutritive sucking to reduce parenteral nutrition-associated cholestasis (PNAC) in preterm infants. Methods: 60 low birth weight preterm infants were randomly divided into non-nutritive sucking and intravenous nutrition and nasogastric feeding group (observation group) and intravenous nutrition and nasal feeding group (control group), 30 cases each. On the first day after birth, On the 14th day, total bile acid, liver function and so on were detected. Results: The levels of total bile acid, total bilirubin, direct bilirubin, and alanine aminotransferase in the observation group were significantly lower than those in the control group on the 14th day after birth (P <0.05). The incidence of parenteral nutrition-related cholestasis The number of cases was significantly lower than that of the control group (P <0.01). The duration of extubation and complete enteral nutrition was significantly shorter than that of the control group (P <0.05). Conclusion: Non-nutritive sucking can reduce the increase of total bile acid, jaundice and alanine aminotransferase induced by intravenous nutrition in preterm infants, reduce the incidence of PNAC and shorten the time of extubation and recovery of total enteral nutrition.