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合成由邻苯二酸酐(Ⅰ)与四氢噻唑(Ⅱ)反应而得。药理实验大鼠诱发的支气管炎ED_(50)口服时约为168mg/kg,静脉注射为1.36mg/吨,本品明显减少其粘液粘度(p<0.01),单次口服和静脉注射以及肌肉重复给药,本品均显活性,且明显高于其它已知的粘痰运动剂(索布瑞醇,乙酰半胱氨酸)。本品(1～10％浓度)对猪胃粘蛋白显示了有中度的流动化活性。经各种途径给药(口服、静脉注射、气雾剂)治疗后,本品显著增加大鼠气管支气管粘
Synthesis of phthalic anhydride (Ⅰ) and tetrahydrothiazole (Ⅱ) reaction derived. Pharmacological experiments induced bronchitis of ED_ (50) when oral administration of about 168mg / kg, intravenous injection of 1.36mg / ton, the goods significantly reduce the mucus viscosity (p <0.01), a single oral and intravenous injection and muscle duplication Administration, the product was significantly active, and significantly higher than other known phlegm movement agent (Sobrellin, acetylcysteine). This product (1 ~ 10% concentration) showed moderate fluidity to porcine gastric mucin. After a variety of ways (oral, intravenous injection, aerosol) treatment, the product significantly increased tracheal bronchial adhesions