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目的探讨奥美拉唑与泮托拉唑治疗胃溃疡患者的临床效果。方法选取2014年1-8月北镇市人民医院收治56例胃溃疡患者作为研究对象,根据随机数字表法将其分为对照组和观察组,各28例。对照组患者口服奥美拉唑,观察组患者采用泮托拉唑进行治疗,比较两组患者的治疗效果、幽门螺杆菌根除情况、复发情况及不良反应发生情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);经过1年随访发现,观察组患者的幽门螺杆菌根除率明显高于对照组,复发率明显低于对照组,差异均有统计学意义(均P<0.05)。结论临床于胃溃疡患者治疗中应用泮托拉唑,可明显提高幽门螺杆菌根除率,降低复发率,临床疗效明显,对缓解和控制患者病情,提高其用药安全性具有积极意义。
Objective To investigate the clinical effects of omeprazole and pantoprazole in the treatment of patients with gastric ulcer. Methods 56 patients with gastric ulcer admitted to Beizhen People’s Hospital from January to August 2014 were selected as the research objects. According to the random number table, they were divided into control group and observation group, 28 cases in each group. Patients in the control group were given omeprazole orally. The patients in the observation group were treated with pantoprazole. The therapeutic effect, eradication of Helicobacter pylori, recurrence and adverse reactions of the two groups were compared. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). After 1-year follow-up, the eradication rate of Helicobacter pylori in observation group was significantly higher than that of control group, and the recurrence rate was significantly higher Lower than the control group, the difference was statistically significant (P <0.05). Conclusion Clinical application of pantoprazole in the treatment of gastric ulcer patients can significantly improve the eradication rate of Helicobacter pylori and reduce the recurrence rate, the clinical curative effect is obvious, to alleviate and control the patient’s condition, improve the safety of the drug has a positive meaning.