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Gresser及其同事们(巴黎的国家研究中心)和Guillon和Riviere(巴斯德研究院)领导了L.Morel-Maroger,P.Ronon,P.Verroust和C.Adam(Tenon医院)D.Woodrow(London)等在干扰素对肾脏的致病作用方面进行了研究。结果要点如下: 1.用外源性干扰素注射新生的小鼠和家兔会引起肾小球基膜损害,随后有免疫球蛋白沉着。 2.内源性干扰素是引起淋巴性脉络丛脑膜炎病毒所致肾小球肾炎负有责任的因素之一。 3.注射外源性干扰素会加剧NZB/W小鼠的肾小球肾炎。因此,这种生物制品对人的肾脏病理学方面会有作用是可能的。注:本文是Richet教授来穗讲演内容
Gresser and colleagues (National Research Center in Paris) and Guillon and Riviere (Pasteur Institute) led L. Morel-Maroger, P. Ronon, P. Verroust and C. Adam (Tenon Hospital) D. Woodrow London) et al. Studied the pathogenic effects of interferon on the kidneys. The main points are as follows: 1. Injection of exogenous interferon into newborn mice and rabbits can cause glomerular basement membrane damage, followed by immunoglobulin calm. 2. Endogenous interferon is caused by lymphocytic choriomeningitis caused by glomerulonephritis responsible for one of the factors. 3. Injection of exogenous interferon exacerbates glomerulonephritis in NZB / W mice. Therefore, it is possible that such biological products have an effect on human renal pathology. Note: This is Professor Richet’s speech