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目的观察放脑脊液连续减压以及鞘内注射治疗隐球菌脑膜炎的临床疗效。方法对照组给予两性霉素B+氟康唑治疗,治疗组在对照组基础上加用鞘内注射两性霉素B和地塞米松以及放脑脊液连续减压治疗,比较两组疗效。结果治疗组治疗总有效率(75%)明显高于对照组(50%),死亡率(25%)低于对照组(50%)。结论鞘内注射两性霉素B、地塞米松以及放脑脊液连续减压治疗可减轻症状,提高好转率,降低死亡率。
Objective To observe the clinical efficacy of continuous cerebrospinal fluid decompression and intrathecal injection for the treatment of cryptococcal meningitis. Methods The control group was treated with amphotericin B + fluconazole. The treatment group was treated with intrathecal amphotericin B, dexamethasone and cerebrospinal fluid by continuous intrathecal decompression in the control group. The curative effect was compared between the two groups. Results The total effective rate (75%) in the treatment group was significantly higher than that in the control group (50%) and the mortality rate (25%) was lower than that in the control group (50%). Conclusion Intrathecal amphotericin B, dexamethasone and cerebrospinal fluid administration can reduce the symptoms, improve the rate of improvement and reduce the mortality rate.